Tsc1 and mtor
WebResults We identified and confirmed multiple mTOR components as recurrently mutated in HBV-associated HCCs. Of significance, we detected frequent (16.2%, n=18/111) mutations of TSC1 and TSC2 genes in the HCC samples. The spectrum of TSC1/2 mutations likely disrupts the endogenous gene functions in suppressing the downstream mTOR activity … WebOct 21, 2024 · The mTOR inhibitor nab-sirolimus (ABI-009) may emerge as an effective and tolerable treatment in patients with gynecologic cancers with TSC1 and TSC2 mutations, …
Tsc1 and mtor
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WebDec 1, 2024 · The mTOR independent effects of Tsc1 loss reported in the literature may be related to the loss of its co-chaperone function and deregulation of clients other than … WebNov 28, 2024 · Purpose Mucosal melanoma is a relatively rare subtype of melanoma for which no clearly established therapeutic strategy exists. The genes of the mTOR signalling pathway have drawn great attention as key targets for cancer treatment, including melanoma. In this study, we aimed to investigate the mutation status of the upstream …
WebSep 1, 2014 · TSC1 controls M1 polarization in an mTOR-independent fashion. To address the role of TSC1 in macrophage polarization, we generated mice with TSC1 deletion, … WebWe interrogated the expression of Tuberous Sclerosis Complex-1 (TSC1; hamartin) and mTOR-related proteins in hippocampal CA1 and CA3 subfields. Methods. A human post …
WebMar 21, 2024 · TSC1 (TSC Complex Subunit 1) is a Protein Coding gene. Diseases associated with TSC1 include Tuberous Sclerosis 1 and Lymphangioleiomyomatosis . Among its related pathways are MTOR signalling and Gene expression (Transcription) . Gene Ontology (GO) annotations related to this gene include binding and chaperone … WebJan 20, 2024 · Tuberous sclerosis complex (TSC), also known as tuberous sclerosis, is a rare genetic disease that causes non-cancerous (benign) tumors to grow in the brain and several areas of the body, including the spinal cord, nerves, eyes, lung, heart, kidneys, and skin. The name tuberous sclerosis comes from the characteristic tuber or potato-like ...
WebMay 12, 2016 · TSC1 and MTOR mutations have also been reported recently in a series of 5 patients with RCC and exceptional responses to mTOR inhibitors . Of 5 patients studied, 2 …
dibrugarh university non cbcs syllabusWebMay 15, 2016 · In this cohort of mRCC patients, mutations in MTOR, TSC1, or TSC2 were more common in patients who experienced clinical benefit from rapalogs than in those … citi-sharepointWebTSC1 (tuberous sclerosis 1) is a gene that encodes for a protein, hamartin, that interacts with a protein encoded by the TSC2 gene, tuberin ( Genetics Home Reference 2013 ). TSC1 acts as a tumor suppressor, through regulation of the mTOR pathway, which is involved in cell proliferation ( Genetics Home Reference 2013 ; PMID: 21533174 ). dibrugarh university noticeWebJun 1, 2014 · Targeted agents against specific molecules participating in gastric carcinogenesis, including those in the mechanistic target of rapamycin (serine/threonine … dibrugarh university msw syllabusWebFeb 26, 2014 · We studied p-mTOR and TSC1 status by immunohistochemical analysis of gastric carcinoma samples using a tissue microarray method and expression values adopted from The Cancer Genome Atlas. Results. High p-mTOR and low TSC1 expression status is associated with adverse clinicopathologic parameters. Patients with high p … dibrugarh university mcaWebOct 29, 2024 · The tuberous sclerosis protein complex (TSC complex) is a key integrator of metabolic signals and cellular stress. In response to nutrient shortage and stresses, the TSC complex inhibits the mechanistic … dibrugarh university locationWebFeb 1, 2014 · This is a study on the role of tuberous sclerosis complex1 (TSC1) mutation and mTOR activation in endothelial cells during angiogenic and embryonic development. … dibrugarh university online thesis tracking