Web(Fezf2+) cortical progenitor cells may be lineage restricted to generate deep-layer neurons (Franco and Mu¨ller, 2013; Wood-worth et al., 2012). To investigate the lineage potential … WebDec 4, 2013 · Expression and function of Fezf2 in the mammillary body Fezf2 has been extensively studied in many other forebrain structures, especially in the cortex where it …

Transcriptional repression by FEZF2 restricts alternative identities of cort…

WebMay 20, 2015 · We recently published a study in which we tested this model using genetic lineage tracing with the Fezf2 and Cux2 loci. This work demonstrated that: (1) Fezf2-expressing (Fezf2 +) RGCs are multipotent and sequentially generate deep and upper layer cortical projection neurons followed by macroglia and (2) RGCs marked by Cux2-CreER … WebOct 7, 2024 · Using this strategy, Fezf2 principal neurons could be further subgrouped into two subfamilies, Fezf2_Lrrk1 and Fezf2_Tle4 (Supplementary Fig. 5c ), and Id2 interneurons could be further... people born on jan 01

Frontiers RNA-Sequencing Analysis Reveals a Regulatory Role for ...

WebThe Cre-ERT2 fusion protein consists of Cre recombinase fused to a triple mutant form of the human estrogen receptor which does not bind its natural ligand (17β-estradiol) at … WebDec 4, 2013 · Upon tamoxifen administration, the Fezf2-CreER T2 allele induces recombination of the RCE-GFP reporter only in progenitor cells and not in postmitotic … Web(A) RT-qPCR detected no change in Fezf2 expression in the cortex or hypothalamus between wild type (WT) and Fezf2CreER mice, proving that 2A-CreER insertion does not affect endogenous expression. n=3. (B-C) E9.5 and E14.5 inductions but not P0 induction of Fezf2CreER::Ai14 labeled cells in the mammillary body, reconfirming the absence of people born on jan 10th