Cd36 clesh domain
WebSep 15, 2001 · Within the carboxy-terminal segment of CD36 is a region of 27 … WebMay 2, 2013 · TSR2 is the Critical TSR Required for CD36 CLESH Binding To confirm that TSR2 is the minimal domain responsible for the CD36 CLESH-dependent anti-migratory activity of TSP-1, we conducted MVEC-d migration assays with TSR (2,3), TSR2 and TSR3 domain constructs.
Cd36 clesh domain
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WebCD36 recognizes at least three classes of extracellular ligands – oxidized phospholipids, long chain fatty acids and proteins containing the so-called thrombospondin type I repeat (TSR) [6–10]. These receptor-ligand interactions mediate effects in a … WebThe extracellular domain of CD36 forms two hydrophobic cavities that bind to ligands such as fatty acids and oxidized LDL (ox-LDL). Moreover, the CLESH domain (CD36, LIMP-2, Emp sequence homologous domain) …
WebEmp sequence homology domain (CLESH) residues of CD36 and the positively charged surface of the thrombo - spondin type I repeat 2 domain of TSP1 (REF. 76). This interaction is required for the ... WebDomain structure of CD36 and proposed ligand binding sites. Indicated regions are: the transmembrane (TM) and membraneassociated (MA) domains; and the CLESH-1 and proline-rich (ProR) regions....
WebJan 29, 2009 · Two different glutathione-S-transferase (GST)/CD36 constructs containing the CLESH domain (spanning amino acids 5–143 and 67–157) were prepared as previously described ( 27 ). The GST fusion proteins were expressed in Escherichia coli Bl21 (DE3) bacteria, induced at log phase with 3 mmol/L of IPTG for 3 h at 37°C. WebCD36 has at least 3 well characterized cellular functions. The first to be described was as a membrane receptor for the matricellular protein thrombospondin-1 (TSP1). On microvascular endothelial cells interaction of TSP1 with CD36 mediates a potent anti-angiogenic effect [ …
WebSep 1, 2003 · CD36 is the cellular receptor for TSP-1 on microvascular endothelium and …
WebMar 1, 2012 · Two domains of the exoplasmic CD36 sequence have been potentially implicated in the binding and endocytosis of apoptotic neutrophils: residues 155-183; and 93-120 (see [7]) The latter domain is... men tapered long hairWebApr 28, 2024 · The extracellular domain of CD36 forms two hydrophobic cavities that … men tapered haircut with beardWebFeb 18, 2010 · The extracellular fragment of BAI1, Vstat120 (V), is released from the cellular membrane via proteolytic cleavage at a G protein–coupled receptor cleavage site.14 It then can act as an anti-angiogenic agent by binding to the CLESH domain of CD36; this initiates an intracellular cascade involving fyn kinase, downstream MAP kinase signaling ... men tapered shortsWebIn summary, we showed with in vitro assays that CD36 phosphorylation directly inhibits … men tapered haircut in the backWebThrombospondin-1 interacts with CD36 CLESH through electrostatic interactions … men tan shirtsWebsite of CD36 is contained within a highly conserved sequence in CD36 family members that we termed the CLESH (CD36 LIMP-II Emp sequence homology) domain (9), which is also found in other proteins. Interestingly, the type I repeat of TSP-1, the domain containing the CD36 binding site, is also found in many other proteins. Characterizing ... men tapered fade cut for shorthairWebSep 1, 2001 · CD36 colocalizes with caveolin-1 in specialized plasma membrane microdomains known as caveolae ( 11 ). These cholesterol- and sphingolipid-enriched structures may serve to concentrate signaling molecules and facilitate the integration of signaling cascades. men tapered cropped pants